Who Will Win The Race Today

© Provided by Quartz Vials of coronavirus disease (COVID-19) vaccine candidate BNT162b2 are sorted at a Pfizer facility in Puurs, Belgium in an undated still image from video.
  1. Who Will Win The Presidential Race Today
  2. Who Will Win Today Match
  3. Who Will Win The Race Today
  4. Who Will Win The Horse Race Today

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  1. But he pitted during a late-race caution and lost the lead (and the win). But that speed is why Elliott has joined Kyle Busch and Martin Truex Jr. Atop the odds board for Wednesday night's race.
  2. The race between Perdue and Ossoff—who would become the youngest member of the Senate if he were to prevail—is much tighter, bookmakers believe. Oddschecker has a Perdue win at 42/41, with an.
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Early on Nov. 18, Pfizer announced the completion of the primary safety and efficacy goals of the third phase of its Covid-19 vaccine clinical trials, and the data are promising: It looks like the two-dose shot prevented 95% of Covid-19 cases. Pfizer, which ran the trial, and BioNTech, which developed the candidate, will file to the US Food and Drug Administration (FDA) for emergency use authorization in the coming days.

Who Will Win The Presidential Race Today

The race to distribute the first Covid-19 vaccine in the US is getting spicy: Pfizer’s announcement comes just days after the Massachusetts-based drug company Moderna announced that early data from its late-stage vaccine trial showed 94% efficacy. And UK-based AstraZeneca, which has teamed up with the University of Oxford, is expected to release some of its own phase three data later this week.

But in reality, being first doesn’t mean winning big: The real Covid-19 vaccine victor will be the one that has the greatest benefits for the widest set of recipients—including the most vulnerable populations. And that race’s winners are far from decided.

At this point, we don’t have full clinical trial data for Pfizer’s or Moderna’s vaccine candidates; all that’s available are press releases from the two companies, which are hardly the same caliber of evidence as peer-reviewed scientific papers. (Both companies havestated that they eventually plan to publish their results in peer-reviewed journals.) But according to the available evidence, there’s reason to believe that these two candidates could be safe and effective for some of the populations at the highest risk of severe Covid-19 cases, including the elderly.


Video: Pfizer says full vaccine results indicate its Covid-19 vaccine is 95% effective (CNBC)

Pfizer says full vaccine results indicate its Covid-19 vaccine is 95% effective

Roughly 80% of Covid-19 deaths in the US have been in adults who are 65 or older. This is partly because older adults are more likely to have pre-existing conditions. But it’s also because older adults’ immune systems are fundamentally different from younger adults.

Who Will Win The Race Today

As Quartz has previously reported, older adults tend to have more active innate immune systems and less active adaptive immune systems. Their bodies often fight off infections with more generalized inflammatory body slams rather than specialized immune responses via antibody production—and those broad responses harm to the rest of the body. That also means it can be tricky to design vaccines that work well for them: Older adults typically have poorer responses to vaccines, and build up fewer antibodies after receiving shots than younger adults.

But in today’s press release, Pfizer stated that its vaccine had an efficacy of 94% in older adults—which would be a big deal if it holds true in the real world, considering the burden of Covid-19 on older adults. Between 41% and 45% of its clinical trial participants were between 56 and 85 years old.

Scientists and healthcare providers have tried all kinds of strategies to improve antibody production from vaccines in older adults, from giving them at specific times of day to prescribing exercise, and even adding chemicals called adjuvants, which boost the body’s immune response to a vaccine. Adding more adjuvants, however, may make side effects worse as they accidentally activate the body’s innate inflammatory response.

But Pfizer’s vaccine is a novel kind of vaccine that uses mRNA (as is Moderna’s). They work differently than other vaccines, providing instructions to the body to make hallmark proteins of viruses, which the body then makes its own defenses against. This process could be why Pfizer’s candidate seems to work with minimal side effects: Only 3.8% of participants who got the vaccine complained of fatigue afterward, and 2% had headaches. Older participants reported them even less frequently. Moderna has not released age-specific data yet, but it has stated that 300 people over 55 participated in its second-phase clinical trial, which is significantly lower than the number of those Pfizer’s trial.

Being able to protect those who are most likely to have severe cases Covid-19 is in the interest of public health and the economy: If we can protect the most vulnerable in society, like the elderly, localities can safely open themselves up for business without putting them at risk. That said, the elderly are not the only demographic at high risk of severe cases. It’s vital that future data from these clinical trials show safety and efficacy among other groups that have been hit disproportionately hard by Covid-19, including people of color, those with pre-existing conditions, and pregnant people. That kind of information will only be available as trials get closer to publishing their final data, and continue collecting data through real-world observational studies.

There has never been a football player in such great demand as Erling Haaland. Lionel Messi and Cristiano Ronaldo may have been the dream signings for every top club in the world for the past decade, and Kylian Mbappe might one day enter that bracket, but none of them right now are in the position that Haaland now enjoys. He can pick whichever A-list team takes his fancy.

Barcelona have paid Messi so well over the years, and won so many trophies, that he is only now, approaching his 34th birthday, able to think about exploiting his free-agent status this summer. But even if he moves on, his huge wages and demands will severely limit his options.

Juventus forward Ronaldo has similarly been tied to Manchester United and Real Madrid for the best years of his career, until those clubs felt able to let him go. As for Mbappe, Paris Saint-Germain's financial power will always give them a level of control over the 22-year-old's future -- even if he is a wanted man.

Haaland's situation is different: the unique combination of the 20-year-old's prodigious talent and contractual situation at Borussia Dortmund means he will enter this summer as the player with the world at his feet. He is the hottest player in the game, and at a time when nearly all of the leading clubs need a prolific centre-forward. Haaland and his advisers are smart enough to know that they can stand back and watch as the scramble to sign him unfolds.

In October 2019, shortly after Haaland scored a hat trick for FC Salzburg on his Champions League debut against Genk, his father, Alfie, told ESPN that each step in Erling's career would be taken with great thought, rather than jumping at the first opportunity to come along.

'If he has choices, you have to be careful with what you choose,' Alfie said. 'We look at the history of the club, the manager, their philosophy.'

Two months later, Haaland rejected a move from Salzburg to Man United, in favour of Dortmund, because of the development path a move to Germany offered. Sources have told ESPN that Haaland and his advisers believe the decision has been justified, and any future move will be taken with the same long-term perspective.

There is a growing likelihood that the next move will happen this summer, a year before a €75m (£64.5m) release clause can be triggered in his Dortmund contract. Dortmund know they could sell for at least double that figure at the end of this season and, if they fail to climb from sixth into the Bundesliga top four and qualify for the Champions League, selling their prized asset may become a financial necessity.

But where is Haaland most likely to go? Don't be fooled into believing he'll simply follow the money and sign the most lucrative deal on the table.

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Almost every major club in the world wants him. United tried and failed to sign him last season, but manager Ole Gunnar Solskjaer continues to regard the player he coached as a teenager at Molde as his No. 1 target.

Chelsea also believe they can do a deal for the Norwegian and lure him to Stamford Bridge, while Manchester City, having identified the need to sign a long-term replacement for the out-of-contract Sergio Aguero, are emerging as a leading candidate to sign the son of Alfie, who made 41 appearances for City between 2000-2002.

The COVID-19 pandemic is likely to impact Liverpool's ability to compete, but they are interested nonetheless, while Real Madrid are regularly linked with a big-money move for the player in the Spanish media.

Juventus have been in the hunt for Haaland since his time at Molde and could return if Ronaldo leaves and frees up space on the wage bill, while Bayern Munich coach Hansi Flick said 'a lot is possible in life, I can't rule that out,' when asked, after Haaland had scored twice against Bayern at the weekend, whether the European champions would be interested in signing him.

Sources close to Haaland will not express a preference for his next club, but they know that interest from all the above sides is genuine, and that each team offers a different challenge and opportunity. They all have their pros and cons, too.

From the outside, City appear to offer the perfect package. They have the financial strength to do a deal and, under Pep Guardiola, are likely to offer the strongest guarantee of challenging for major trophies. City are desperate to win the Champions League, as is Haaland, and it's clear they would be a formidable force together.

But Haaland is a player with ambitions to play in all of Europe's big leagues, in a similar fashion to Zlatan Ibrahimovic, and moving to City would make that difficult. City, quite simply, don't lose their star players, so a move to the Etihad would be for the long term.

United, on the other hand, would sell the challenge of being the man to carry the club back to the top by being a modern-day version of Eric Cantona. United have lost their place among the elite clubs challenging for the biggest prizes, but the commercial value to Haaland of being their star player would be huge due to United's global popularity, and that could be a compelling offer -- especially if Solskjaer, who remains close to Haaland, continues as manager.

Chelsea could match the money City and United would offer, and use the pull of London to tempt Haaland to Stamford Bridge. Only City have won more trophies in England over the past 10 years, so Haaland would be signing for a club capable of winning silverware, albeit one that lacks consistency due to the ever-decreasing shelf-life of their managers.

Liverpool's slump in recent weeks could cost them a place in next season's Champions League and end any faint hopes of signing Haaland, but if he's tempted by the prospect of playing at Anfield and joining the club's list of legendary names, the romantic appeal of signing for the Premier League champions could be persuasive.

Who Will Win Today Match

As for Real Madrid, they can outdo United for global appeal and star quality. They can also give Haaland the chance to dominate La Liga just as Ronaldo and Messi have over the years. And while their Champions League pedigree is a huge draw, doubts remain over whether Real can afford Haaland in the wake of the pandemic.

Who Will Win The Race Today

Juventus can offer Champions League football and another steppingstone towards a move further down the line. If Haaland succeeds in Italy, he could then head to England or Spain before he is even in his mid-20s.

And then there's Bayern. Robert Lewandowski has already shown what riches await for a centre-forward prepared to leave Dortmund for the Allianz Arena, and Haaland could be the perfect long-term successor for the 32-year-old Poland international. But just like a move to City, Bayern would offer trophies, but they may also expect him to stay for 10 years.

Who Will Win The Horse Race Today

Whichever way it plays out, Haaland can only end up as a winner. With such an array of stellar clubs on his tail, it's impossible to make a bad choice. Sources have made it clear to ESPN that the one factor that won't drive Haaland's next decision is money. It will be about the most enticing challenge and the most compelling story. That chapter is yet to be written.

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